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Newly Approved Epilepsy Drug Significantly Cuts Seizure Frequency
Monday, December 9, 2019
Adjunctive cenobamate may help reduce seizure frequency for patients with focal epilepsy, regardless of the number of antiseizure medicines patients take or the severity or duration of their illness. Medscape Medical News
AHA Scientific Statement on Managing Elderly in Cardiac ICU
Monday, December 9, 2019
The statement highlighted the many comorbidities that geriatric patients in the cardiac intensive care unit may have, including frailty and cognitive impairment, and suggested management strategies. Medscape Medical News
Two More Alzheimer's Drug Candidates Fail
Monday, December 9, 2019
The BACE inhibitor lanabecestat and the antibiotic minocycline failed to slow cognitive decline in randomized controlled trials. Medscape Medical News
In Follicular Lymphoma, Can MRD Predict Relapse or Define Cure?
Monday, December 9, 2019
In a first-of-its-kind study, patients with follicular lymphoma who were in remission were followed for minimal residual disease (MRD) status, which may guide treatment. Medscape Medical News
Aspirin Plus a DOAC May Do More Harm Than Good in Some
Monday, December 9, 2019
For some patients, combining aspirin and direct oral anticoagulant (DOAC) therapy may increase the rates of bleeding without protecting them from adverse thrombotic outcomes, a new study has found. Medscape Medical News
Study Halted; 'Hyperprogression' Seen With Nivolumab for R/R PTCL
Monday, December 9, 2019
A phase 2 study suggests the checkpoint inhibitor is not the hoped-for salvage treatment in relapsed or refractory peripheral T-cell lymphoma. Medscape Medical News
'Great News': CAR T Cells Are Effective and Safe in Babies
Monday, December 9, 2019
Treatment of infants with relapsed or refractory ALL was as effective and safe as in populations of older children and adolescents. Medscape Medical News
Poor Sleep Worsens Recovery From Chronic Low Back Pain
Monday, December 9, 2019
Insomnia and co-existing sleeplessness and musculoskeletal pain were inversely related to long-term recovery from chronic low back pain, a study found; relieving sleep problems may improve recovery. Medscape Medical News
New FDA Policy May Speed Biosimilar Insulins to US Market
Monday, December 9, 2019
But the new guidance may not have a big impact on price, despite the agency's pronouncements. Medscape Medical News
Oncologist Confidential: I Want My OR to Be 'A Joyous Place'
Monday, December 9, 2019
'I think that it's important that the operating room be a happy place, even a joyous place, because this is an opportunity to kick cancer's butt and give people back their lives.' Medscape Medical News
GPs' Discussion of Weight With Patients Rare, and Mainly Negative
Monday, December 9, 2019
Overweight patients have largely negative interactions with physicians about their weight, even though these interactions are few and far between. Medscape Medical News
Forced Drug Abuse a 'Disturbingly Common' Part of Domestic Violence
Monday, December 9, 2019
Domestic violence is not just about physical battering and emotional abuse, it can also include forcing a partner to become and stay addicted to drugs, a phenomenon that is 'disturbingly common.' Medscape Medical News
Cannabis Drug Promising for Seizures Linked to Tuberous Sclerosis
Monday, December 9, 2019
A cannabidiol-derived drug approved for the treatment of Dravet and Lennox-Gastaut syndromes also reduces seizures in patients with tuberous sclerosis complex. Medscape Medical News
Allogeneic Transplant Best in Follicular Lymphoma, but Worth It?
Sunday, December 8, 2019
Long-term data show better overall survival after an allogeneic transplant for relapsed follicular lymphoma than with autologous transplant, but an expert wonders about recommending transplant at all. Medscape Medical News
Increase in Autologous HSCT for Myeloma, Decline in Allogeneic
Sunday, December 8, 2019
Autologous hematopoietic stem cell transplants have increased globally, but predominantly in high income nations, and there are marked disparities in usage. Medscape Medical News
No Decreased Survival in Blacks With AML Compared With Whites
Sunday, December 8, 2019
Although blacks with acute myeloid leukemia were more likely to have evidence of abnormal kidney function, the excess of this comorbidity didn't affect overall survival, compared with whites. Medscape Medical News
Some Patients with DLBCL Can Skip Radiation: 'It's a Win'
Sunday, December 8, 2019
A 'no radiation' approach may be possible for managing non-bulky (stage I/II) disease in patients with DLBCL. These patients may do well with just 4 cycles of R-CHOP after an interim PET-negative scan. Medscape Medical News
Myeloma Patients Over Age 70 Can Benefit From Auto-HC Transplant
Sunday, December 8, 2019
"Age has no implication in terms of the antimyeloma effect of transplant," said one oncologist. Researchers called this largest study of auto-HCT in older adults with multiple myeloma. Medscape Medical News
An Off-the-Shelf Drug to Rival CAR T Cells: 'Very Exciting'
Saturday, December 7, 2019
A novel bispecific antibody, mosunetuzumab, has shown complete remissions in patients with poor prognosis non-Hodgkin's lymphoma, even those previously treated with CAR T cells. Medscape Medical News
'Real-World' Data Show CAR-T Therapies Are Cost Effective
Saturday, December 7, 2019
CAR-T cell therapy comes with a formidable sticker price, but a new study showed that it can actually reduce healthcare expenditures in the long term. Medscape Medical News